Journal: Revista Médica del Instituto Mexicano del Seguro Social

Article Title: Desenlaces clínicos de la intervención percutánea sobre tronco coronario izquierdo no protegido

doi: 10.5281/zenodo.10278143

Figure Lengend Snippet: HAS: hipertensión arterial sistémica; EAC: enfermedad arterial coronaria; EPOC: enfermedad pulmonar obstructiva crónica; SCASEST: síndrome coronario agudo sin elevación del ST; SCACEST: síndrome coronario agudo con elevación del ST; FEVI: fracción de eyección del ventrículo izquierdo *Las variables señaladas tuvieron diferencia estadísticamente significativa

Article Snippet: La enfermedad coronaria trivascular y la enfermedad del tronco coronario izquierdo (TCI) son lesiones de alto riesgo, con importante mortalidad.

Techniques:

Journal: Revista Médica del Instituto Mexicano del Seguro Social

Article Title: Desenlaces clínicos de la intervención percutánea sobre tronco coronario izquierdo no protegido

doi: 10.5281/zenodo.10278143

Figure Lengend Snippet: TCI: tronco coronario izquierdo; DA: descendente anterior; OTC: oclusión total crónica; IVUS: intravascular ultrasound , por sus siglas en inglés; BIAC: balón intraaórtico de contrapulsación

Article Snippet: La enfermedad coronaria trivascular y la enfermedad del tronco coronario izquierdo (TCI) son lesiones de alto riesgo, con importante mortalidad.

Techniques:

Journal: Medical Sciences

Article Title: Assessment of Cardiovascular Disease Risk and Therapeutic Patterns among Urban Black Rheumatoid Arthritis Patients

doi: 10.3390/medsci7020031

Figure Lengend Snippet: Cardiovascular risk factors and outcomes considering the serotype.

Article Snippet: The examined CVD outcomes included myocardial infarction (MI) or known coronary artery disease (CAD) (19.8%), which were similar to those reported in the CORRONA study [ ].

Techniques:

Journal: Nature Communications

Article Title: Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

doi: 10.1038/s41467-020-17374-3

Figure Lengend Snippet: a Risk of coronary artery disease by monogenic and polygenic risk strata (case-control study; n = 12,852). Carriers and noncarriers were stratified into three groups according to their polygenic score—low, intermediate, or high defined as the lowest quintile, the middle three quintiles, and the highest quintile of the polygenic score distribution, respectively. The odds ratio was assessed in a logistic regression model with age, sex, and the first four principal components of ancestry as covariates. Noncarriers with intermediate polygenic score served as the reference group. The black boxes indicate the adjusted odds ratio. The horizontal lines around the black boxes indicate the 95% confidence intervals. b Predicted odds ratio for coronary artery disease in each percentile (dots) of the polygenic score distribution for carriers (blue) and noncarriers (black) of familial hypercholesterolemia variants in the cohort study derived from the UK Biobank ( n = 48,812). Noncarriers with median polygenic score served as the reference group. c Predicted probability of coronary artery disease by age 75 years in each percentile (dots) of the polygenic score distribution for carriers (blue) and noncarriers (black) of familial hypercholesterolemia variants in the cohort study derived from the UK Biobank ( n = 48,812). The shaded area around the dots represents the 95% confidence interval. The horizontal dashed lines show the probability of disease for people with average polygenic risk score. FH familial hypercholesterolemia. p -values in the figure were estimated by the Wald Test. Statistical significance was set at p < .05, and two-sided p values were used.

Article Snippet: The raw weights for calculating the coronary artery disease polygenic score are available for download from the Broad Institute Cardiovascular Disease Knowledge Portal ( http://www.broadcvdi.org ).

Techniques: Control, Derivative Assay

Journal: Nature Communications

Article Title: Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

doi: 10.1038/s41467-020-17374-3

Figure Lengend Snippet: a Risk of breast cancer by monogenic and polygenic strata (case-control study; n = 19,264). Carriers and noncarriers were stratified into three groups according to their polygenic score—low, intermediate, or high defined as the lowest quintile, the middle three quintiles, and the highest quintile of the polygenic score distribution, respectively. The odds ratio was assessed in a logistic regression model with age and the first four principal components of ancestry as covariates. Noncarriers with intermediate polygenic score served as the reference group. The black boxes indicate the adjusted odds ratio. The horizontal lines around the black boxes indicate the 95% confidence intervals. b Predicted odds ratio for breast cancer in each percentile (dots) of the polygenic score distribution for carriers (blue) and noncarriers (black) of hereditary breast and ovarian cancer variants in the cohort study derived from the UK Biobank ( n = 26,597). Noncarriers with median polygenic score served as the reference group. c Predicted probability of coronary artery disease by age 75 years in each percentile (dots) of the polygenic score distribution for carriers (blue) and noncarriers (black) of hereditary breast and ovarian cancer variants in the cohort study derived from the UK Biobank ( n = 26,597). The shaded area around the dots represents the 95% confidence interval. The horizontal dashed lines show the probability of disease for people with average polygenic risk score. HBOC hereditary breast and ovarian cancer. p -values in the figure were estimated by the Wald Test. Statistical significance was set at p < .05, and two-sided p values were used.

Article Snippet: The raw weights for calculating the coronary artery disease polygenic score are available for download from the Broad Institute Cardiovascular Disease Knowledge Portal ( http://www.broadcvdi.org ).

Techniques: Control, Derivative Assay

Journal: Nature Communications

Article Title: Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

doi: 10.1038/s41467-020-17374-3

Figure Lengend Snippet: a Predicted odds ratio for colorectal cancer in each percentile (dots) of the polygenic score distribution for carriers (blue) and noncarriers (black) of Lynch syndrome variants in the cohort study derived from the UK Biobank ( n = 48,812). Noncarriers with median polygenic score served as the reference group. b Predicted probability of colorectal cancer by age 75 years in each percentile (dots) of the polygenic score distribution for carriers (blue) and noncarriers (black) of Lynch syndrome variants in the cohort study derived from the UK Biobank ( n = 48,812). The shaded area around the dots represents the 95% confidence interval. The horizontal dashed lines show the probability of disease for people with average polygenic risk score.

Article Snippet: The raw weights for calculating the coronary artery disease polygenic score are available for download from the Broad Institute Cardiovascular Disease Knowledge Portal ( http://www.broadcvdi.org ).

Techniques: Derivative Assay

Journal: Nature Communications

Article Title: Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

doi: 10.1038/s41467-020-17374-3

Figure Lengend Snippet: Baseline characteristics of coronary artery disease case-control study participants.

Article Snippet: The raw weights for calculating the coronary artery disease polygenic score are available for download from the Broad Institute Cardiovascular Disease Knowledge Portal ( http://www.broadcvdi.org ).

Techniques:

Journal: BMJ Open

Article Title: Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review

doi: 10.1136/bmjopen-2021-053674

Figure Lengend Snippet: Examples of clinically approved omics-derived diagnostic or prognostic tests designs applied to personalised medicine (synonyms for the same test are separated by the ‘/’-symbol)

Article Snippet: The first clinically validated LDT for a cardiovascular indication derived from omics data was the Corus coronary artery disease (CAD) test, developed to identify CAD in stable non-diabetic patients.

Techniques: Diagnostic Assay, Microarray, Gene Expression, Biomarker Discovery, DNA Sequencing, Mutagenesis, Derivative Assay, Sequencing